ABSTRACT
Aptamers have shown great potential in early diagnosis,treatment of tumor because of its high specificity and affinity.The aptamers selected by cell-SELEX can identify tumor cells through target molecular changes,and then realize the prevention and treatment of tumors.At present,researchers have successfully selected a number of aptamers by using cell-SELEX technology combined with flow cytometry.To make up for the deficiencies and exert the advantages of aptamers can make aptamer technology really apply to clinical diagnosis and treatment.
ABSTRACT
Nucleic acid aptamer is an oligonucleotide sequence screened by the exponential enrichment ligand system evolution technology (SELEX). Previous studies have shown that nucleic acid aptamer has a good application prospect in tumor diagnosis and treatment. Therefore, we reviewed the selection and identification of nucleic acid aptamer of lung cancer cells in recent years, and discussed the effect of aptamer as targeting drugs and targeting vectors on the diagnosis of tumors, which provide a new idea for early diagnosis and treatment of tumor.